PORTO @ Archivio Istituzionale della Ricerca

Blockade of YAP Mechanoactivation Prevents Neointima Formation and Adverse Remodeling in Arterialized Vein Grafts

Background: Bypass surgery using saphenous vein (SV) grafts is commonly performed to revascularize the ischemic heart and lower limbs. These interventions have limited success due to adverse remodeling caused by overproliferation of smooth muscle cells in the intima layer, leading to progressive bypass stenosis. We previously showed that cyclic strain deriving from exposure to coronary flow induces the expression of the matricellular protein thrombospondin-1 in the human SV, promoting activat...

TCAD accurate modeling of trap-induced effects in GaN HEMTs

In this work we demonstrate an accurate Technology Computer Aided Design (TCAD) modeling approach for the analysis of trap effects on the electrical features of AlGaN/GaN HEMT devices for microwave applications. The physical device model includes the discretized coupled drift-diffusion and trap rate equations system, implemented into an in-house mixed-mode TCAD simulator, and solved in dynamic conditions with the Harmonic Balance (HB) algorithm. The TCAD allows a seamless assessment of the DC...

Design and Extensive NPR Characterization of a Highly Linear SatCom GaN MMIC Doherty PA

This article presents the design strategy and extensive noise-to-power ratio (NPR)-focused characterization of a state-of-the-art Doherty power amplifier (DPA) for satellite applications in the Ka-band downlink (17.3-20.3 GHz), fabricated using a commercial 100-nm GaN-Si high electron mobility transistor technology. The design aims for high gain and good intrinsic linearity over a 3-GHz bandwidth by adopting an amplifying chain with limited phase distortion and a Doherty combiner designed to ...

1H NMR Urinary Metabolomics Profiling of Newborns with Congenital Human Cytomegalovirus Infection: Insights into Metabolic Alterations