This paper proposes a pulse-modulated controller that generates, under stationary conditions, a desired sequence of uniform and equidistant impulsive control actions from continuous measurements of the output of a smooth nonlinear time-invariant positive single-input single-output plant of Wiener structure. The proposed controller is applied to the dosing of the drug atracurium in closed-loop neuromuscular blockade and its performance is studied on a database of patient-specific pharmacokinetic-pharmacodynamic models previously estimated from clinical data.
Design of Impulsive Feedback Controller for Dosing / Medvedev, Alexander; Proskurnikov, Anton V.; Zhusubaliyev, Zhanybai T.. - ELETTRONICO. - (2024), pp. 227-232. (Intervento presentato al convegno 32nd Mediterranean Conference on Control and Automation (MED) tenutosi a Chania - Crete (Greece) nel 11-14 June 2024) [10.1109/med61351.2024.10566219].
Design of Impulsive Feedback Controller for Dosing
Proskurnikov, Anton V.;
2024
Abstract
This paper proposes a pulse-modulated controller that generates, under stationary conditions, a desired sequence of uniform and equidistant impulsive control actions from continuous measurements of the output of a smooth nonlinear time-invariant positive single-input single-output plant of Wiener structure. The proposed controller is applied to the dosing of the drug atracurium in closed-loop neuromuscular blockade and its performance is studied on a database of patient-specific pharmacokinetic-pharmacodynamic models previously estimated from clinical data.File | Dimensione | Formato | |
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https://hdl.handle.net/11583/2991462