The most popular approach to explain cancer is based on the discovery of oncogenes and tumor suppressor genes as a preliminary step in estimating their impact on altered pathways. The present paper proposes a pipeline which aims at detecting “weak” or “indirect” functions impacted by Copy Number Variations (CNVs) of cancer-related genes, integrating such signals over all known oncogenes/tumor suppressor genes of a cancer type. We applied the pipeline to the task of detecting the aberrant functional effects of these alterations across ovarian cancer patients from The Cancer Genome Atlas (TCGA) data.
A transcriptional study of oncogenes and tumor suppressors altered by copy number variations in ovarian cancer / Giacomini, G.; Ciravegna, G.; Pellegrini, M.; D'Aurizio, R.; Bianchini, M.. - 192:(2020), pp. 159-169. (Intervento presentato al convegno 8th KES International Conference on Innovation in Medicine and Healthcare, KES-InMed 2020 tenutosi a Virtual Conference nel June 17–19, 2020) [10.1007/978-981-15-5852-8_15].
A transcriptional study of oncogenes and tumor suppressors altered by copy number variations in ovarian cancer
Ciravegna G.;
2020
Abstract
The most popular approach to explain cancer is based on the discovery of oncogenes and tumor suppressor genes as a preliminary step in estimating their impact on altered pathways. The present paper proposes a pipeline which aims at detecting “weak” or “indirect” functions impacted by Copy Number Variations (CNVs) of cancer-related genes, integrating such signals over all known oncogenes/tumor suppressor genes of a cancer type. We applied the pipeline to the task of detecting the aberrant functional effects of these alterations across ovarian cancer patients from The Cancer Genome Atlas (TCGA) data.Pubblicazioni consigliate
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https://hdl.handle.net/11583/2980671