Purpose: The evaluation of a mini or simulated fluid challenge is still a complex and open issue in the clinical setting and it is of paramount significance for the fluid therapy optimization. We here investigated the capacity of a new hemodynamic parameter, the venous Pulse Wave Velocity (vPWV), to detect the effect of passive leg raising (PLR). Materials and methods: In 15 healthy volunteers (7 M, 8 F, age 26 ± 3) venous pressure pulses were elicited by pneumatic compressions of the left hand and proximally detected by ultrasound for calculation of the vPWV. We also non-invasively measured the basilic vein (BV) cross-sectional perimeter, and peripheral venous pressure (PVP). The PLR manoeuvre was performed twice to evaluate reliability of the assessment. Results: The PLR had an overall statistically significant effect on the entire set of variables (MANOVA, p < 0.05): vPWV increased from 2.11 ± 0.46 to 2.30 ± 0.47 m/s (p = 0.01; average increase: 10%). This effect was transient and dropped below 5% after about 3 min. A significant increase was also exhibited by BV size and PVP. In consecutive measurements vPWV showed little intra-subject variability (CoV = 8%) and good reliability (ICC = 0.87). Finally, the vPWV responses to the two PLRs exhibited good agreement (paired T-test: p = 0.96), and moderate reliability (ICC = 0.57). Conclusion: These results demonstrated that vPWV can be non-invasively, objectively and reliably measured in healthy subjects and that it is adequate to detect small pressure/volume variations, as induced by PLR-from-supine. These characteristics make it suitable for clinical applications.
Venous Pulse Wave Velocity variation in response to a simulated fluid challenge in healthy subjects / Ermini, L.; Chiarello, N. E.; De Benedictis, C.; Ferraresi, C.; Roatta, S.. - In: BIOMEDICAL SIGNAL PROCESSING AND CONTROL. - ISSN 1746-8094. - ELETTRONICO. - 63(2020), p. 102177.
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|Titolo:||Venous Pulse Wave Velocity variation in response to a simulated fluid challenge in healthy subjects|
|Data di pubblicazione:||2020|
|Digital Object Identifier (DOI):||http://dx.doi.org/10.1016/j.bspc.2020.102177|
|Appare nelle tipologie:||1.1 Articolo in rivista|
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