Mechanical characterization of glass-ceramic scaffolds at multiple characteristic lengths through nanoindentation

The mechanical behaviour of implantable scaffolds is of relevant interest in all applications which require load-bearing capability. This study aims at establishing a quantitative relationship between the mechanical properties of glass-ceramic scaffolds for bone repair and the nano/micro-scale properties of their constituent materials. A nanoindentation study is carried out spanning different penetration depth on bulk (pore-free) glass-ceramic samples and on the walls of porous scaffolds. Micro-tomographical investigations allow assessing small-scale porosity of the scaffold walls. A simple homogenization model is used to establish the relationship between the elastic modulus of the bulk material and that of the micro-porous walls of the scaffolds. The elastic modulus of scaffold walls was found to be approximately 50%lower than that of the bulk glass-ceramic. The properties estimated experimentally on the walls of the scaffolds are quantitatively consistent with the analytical predictions provided by the homogenization model and the micro-porosity measured through tomographical analyses