Generative AI Pipeline with Model-Guided Filtering for Sim-to-Real Transfer in Surgical Imaging

Automating surgical suturing requires reliable computer vision systems, yet annotated real surgical datasets remain scarce, costly, and difficult to obtain. To address this challenge, we introduce a data-centric pipeline that combines synthetic data generation, generative realism boosting, and model-guided filtering to improve sim-toreal transfer without relying on real annotated surgical footage. Synthetic images were created in Unity with both type-based and part-based instruments annotations, then enhanced using CycleGAN-TURBO for unpaired imageto-image translation and Real-ESRGAN for high-resolution restoration. A YOLO-based selector model, trained on synthetic images, assessed the quality of generatively enhanced data through Dice similarity scoring, discarding samples with distortions or misalignments. In the part-based configuration, on a real test set, the baseline model trained solely on synthetic images achieved a Dice score of 0.17, while combining synthetic with unfiltered enhanced data reached 0.24. Filtering proved decisive: accepted enhanced images combined with a synthetic (hybrid curated dataset) further boosted scores to 0.44. Fine-tuning strategies yielded only marginal gains, confirming that improvements were driven primarily by data quality rather than training variations. In the typebased setup, the hybrid curated dataset achieved a mean Dice score of 0.65, a substantial improvement over previous fully synthetic baselines (0.384) without requiring real training annotations. These results demonstrate that curation of generative outputs is critical for sim-to-real transfer in surgical vision. By uniting synthetic generation, generative realism, and automated filtering, this pipeline enables scalable, low-cost dataset creation, providing resources on GitHub and a reproducible foundation for developing reliable perception systems and advancing autonomy in surgical robotics.