Spray freeze-dried microparticles (MPs) can be efficiently delivered to the lungs due to their low density and good flowability. However, particle size should be tuned to achieve high fine particle fraction (FPF) and low mass median aerodynamic diameter (MMAD). In this study, MPs composed of mannitol and salbutamol sulphate (SS) were produced by pneumatic SFD. The relationship between the operative variables and the particle size was assessed through a model, associated with a face centered design of experiments (FCD). Moreover, the role of crystallinity in determining MPs flowability was evaluated upon the incorporation of L-leucine (LL). A reduced crystallinity and the presence of δ-mannitol alone significantly improved the aerosolization properties of MPs up to maximum FPF (48%) and minimum MMAD (2 μm) at 10% (w/wdw) LL. This result disclosed the influence of polymorphism on the MPs’ adhesion cohesiveness, proving the dependency of the MPs’ aerodynamics on LL and mannitol crystallinity.

Spray Freeze-Drying for Inhalable L-leucine, Mannitol-based Microparticles: The Impact of Process Variables, L-leucine, and Crystallinity on Aerosolization Properties / Pasero, Lorena; Sulpizi, Adamo; Guidi, Tomaso; Pisano, Roberto. - (2024). (Intervento presentato al convegno 2024 ISLFD International Conference nel May 8-10 2024).

Spray Freeze-Drying for Inhalable L-leucine, Mannitol-based Microparticles: The Impact of Process Variables, L-leucine, and Crystallinity on Aerosolization Properties

Lorena Pasero;Roberto Pisano
2024

Abstract

Spray freeze-dried microparticles (MPs) can be efficiently delivered to the lungs due to their low density and good flowability. However, particle size should be tuned to achieve high fine particle fraction (FPF) and low mass median aerodynamic diameter (MMAD). In this study, MPs composed of mannitol and salbutamol sulphate (SS) were produced by pneumatic SFD. The relationship between the operative variables and the particle size was assessed through a model, associated with a face centered design of experiments (FCD). Moreover, the role of crystallinity in determining MPs flowability was evaluated upon the incorporation of L-leucine (LL). A reduced crystallinity and the presence of δ-mannitol alone significantly improved the aerosolization properties of MPs up to maximum FPF (48%) and minimum MMAD (2 μm) at 10% (w/wdw) LL. This result disclosed the influence of polymorphism on the MPs’ adhesion cohesiveness, proving the dependency of the MPs’ aerodynamics on LL and mannitol crystallinity.
2024
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11583/2992129