A Constructal law perspective of cancer’s volume/area expansion ratio

Constructal law is used to improve the analysis of the resonant heat transfer in cancer cells. The result highlights the fundamental role of the volume/area ratio and of its role in cancer growth and invasion. Cancer cells seek to increase their surface area to facilitate heat dissipation; as such this tumour expansion ratio declines as malignant cells start to migrate and the cancer expands spatially, both locally and, eventually, systemically. Consequently, we deduce that effective anti-cancer therapy should be based on the control of some ion transport phenomena in an effort to increase the volume/area ratio. This emphasizes restricting local and systemic spatial expansion of the tumour system and thus gives further credence to the superior role of novel anti-migratory and anti-invasive treatment strategies, over conventional anti-proliferative options only.