Anesthesia, despite being the cornerstone of modern surgery, is to this date a biological puzzle. While scientific efforts still have not managed to frame its pharmacology in an exhaustive theoretical framework, microtubules inside neurons are thought to be essential for memory formation and consciousness. The potential ability of volatile anesthetics to alter or dampen the vibrational properties of microtubules justifies the spatiotemporal characterization of the interaction between such molecules and the tubulin dimer through the use of computational molecular modelling.

Molecular Dynamics And Binding Mechanisms Of Volatile Anesthetics Targeting Human Tubulin / Zizzi, Eric Adriano; Cavaglià, Marco; Deriu, Marco Agostino; Tuszynski, Jacek Adam. - ELETTRONICO. - (2021). ((Intervento presentato al convegno 26th Congress of the European Society of Biomechanics tenutosi a Milan (IT) nel July 11-14, 2021.

Molecular Dynamics And Binding Mechanisms Of Volatile Anesthetics Targeting Human Tubulin

Zizzi, Eric Adriano;Cavaglià, Marco;Deriu, Marco Agostino;Tuszynski, Jacek Adam
2021

Abstract

Anesthesia, despite being the cornerstone of modern surgery, is to this date a biological puzzle. While scientific efforts still have not managed to frame its pharmacology in an exhaustive theoretical framework, microtubules inside neurons are thought to be essential for memory formation and consciousness. The potential ability of volatile anesthetics to alter or dampen the vibrational properties of microtubules justifies the spatiotemporal characterization of the interaction between such molecules and the tubulin dimer through the use of computational molecular modelling.
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11583/2940059