Freeze-thawing of liposomes: investigation of cryoprotectants for freeze-drying

Liposomes are phospholipid membranes widely used for drug delivery in biomedical applications. They can retain, protect and deliver macromolecules to target tissues and then control the release of their cargoes. To exploit this function, the liposomal membrane integrity is crucial to avoid undesired leakage of cargoes. In this work, the influence of low temperature storing conditions on the stability of liposomes is investigated for further delivery applications.