Archivio Istituzionale della RicercaPolymorphism is known as the ability of a compound to exist in more than one crystalline structure, and is very common in the crystallization of active pharmaceutical ingredients (APIs). Polymorph screening is fundamental during the development of new drugs since the formation of the wrong polymorph can affect solubility, rate of dissolution and toxicity of the API, therefore, seriously threatening the life of patients [1]. This work reports a novel microfluidic method for studying polymorphism based on multiplex fluoropolymer microfluidic devices.
Application of a multiplex microfluidic platform to fast polymorph screening of pharmaceutical compounds / Simone, E.; Mcveigh, J.; Nagy, Z. K.; Reis, N. M.. - (2016), pp. 910-911. (Intervento presentato al convegno 20th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2016 tenutosi a irl nel 2016).
Application of a multiplex microfluidic platform to fast polymorph screening of pharmaceutical compounds
Simone E.;
2016
Abstract
Polymorphism is known as the ability of a compound to exist in more than one crystalline structure, and is very common in the crystallization of active pharmaceutical ingredients (APIs). Polymorph screening is fundamental during the development of new drugs since the formation of the wrong polymorph can affect solubility, rate of dissolution and toxicity of the API, therefore, seriously threatening the life of patients [1]. This work reports a novel microfluidic method for studying polymorphism based on multiplex fluoropolymer microfluidic devices.
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https://hdl.handle.net/11583/2934359