A 300mV-Supply, 144nW-Power, 0.03mm2-Area, 0.2-PEF Digital-Based Biomedical Signal Amplifier in 180nm CMOS

This paper presents a power-efficient Ultra Low Voltage (ULV) Fully-Differential (FD) Digital-Based Operational Transconductance Amplifier for Biomedical signal processing (BioDIGOTA), which digitally processes biological analog signals using CMOS standard-cells. Post-layout simulations, including parasitic effects in 180nm CMOS technology, show that BioDIGOTA consumes only 144 nW at 300 mV of supply voltage while driving a 20pF capacitive load, with a power efficiency factor (PEF) lower than 1. The layout uses 0.03 mm2 of the total silicon area, excluding I/0 pads. The proposed BioDIGOTA proves that digital-based analog design can be adopted in biomedical signal amplifiers, lowering the total silicon area by 2.3X times compared to the current state of the art landscape while keeping reasonable power and system performance.