Cellular adhesion provides one of the fundamental forms of biological interaction between cells and their surroundings, yet the continuum modelling of cellular adhesion has remained mathematically challenging. In 2006, Armstrong et al. proposed a mathematical model in the form of an integro-partial differential equation. Although successful in applications, a derivation from an underlying stochastic random walk has remained elusive. In this work we develop a framework by which non-local models can be derived from a space-jump process. We show how the notions of motility and a cell polarization vector can be naturally included. With this derivation we are able to include microscopic biological properties into the model. We show that particular choices yield the original Armstrong model, while others lead to more general models, including a doubly non-local adhesion model and non-local chemotaxis models. Finally, we use random walk simulations to confirm that the corresponding continuum model represents the mean field behaviour of the stochastic random walk.
A space-jump derivation for non-local models of cell–cell adhesion and non-local chemotaxis / Buttenschon, A.; Hillen, T.; Gerisch, A.; Painter, K. J.. - In: JOURNAL OF MATHEMATICAL BIOLOGY. - ISSN 0303-6812. - ELETTRONICO. - 76:1-2(2018), pp. 429-456. [10.1007/s00285-017-1144-3]
|Titolo:||A space-jump derivation for non-local models of cell–cell adhesion and non-local chemotaxis|
|Data di pubblicazione:||2018|
|Digital Object Identifier (DOI):||http://dx.doi.org/10.1007/s00285-017-1144-3|
|Appare nelle tipologie:||1.1 Articolo in rivista|