A rigorous limit procedure is presented which links nonlocal models involving adhesion or nonlocal chemotaxis to their local counterparts featuring haptotaxis and classical chemotaxis, respectively. It relies on a novel reformulation of the involved nonlocalities in terms of integral operators applied directly to the gradients of signal-dependent quantities. The proposed approach handles both model types in a unified way and extends the previous mathematical framework to settings that allow for general solution-dependent coefficient functions. The previous forms of nonlocal operators are compared with the new ones introduced in this paper and the advantages of the latter are highlighted by concrete examples. Numerical simulations in 1D provide an illustration of some of the theoretical findings.

Nonlocal and local models for taxis in cell migration: a rigorous limit procedure / Eckardt, M.; Painter, K. J.; Surulescu, C.; Zhigun, A.. - In: JOURNAL OF MATHEMATICAL BIOLOGY. - ISSN 0303-6812. - ELETTRONICO. - 81:6-7(2020), pp. 1251-1298. [10.1007/s00285-020-01536-4]

Nonlocal and local models for taxis in cell migration: a rigorous limit procedure

Painter K. J.;
2020

Abstract

A rigorous limit procedure is presented which links nonlocal models involving adhesion or nonlocal chemotaxis to their local counterparts featuring haptotaxis and classical chemotaxis, respectively. It relies on a novel reformulation of the involved nonlocalities in terms of integral operators applied directly to the gradients of signal-dependent quantities. The proposed approach handles both model types in a unified way and extends the previous mathematical framework to settings that allow for general solution-dependent coefficient functions. The previous forms of nonlocal operators are compared with the new ones introduced in this paper and the advantages of the latter are highlighted by concrete examples. Numerical simulations in 1D provide an illustration of some of the theoretical findings.
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Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/11583/2867012