Osteochondral defects are focal areas of damage involving articular cartilage and sub-chondral bone. Tissue engineering scaffolds are used to improve the organism regeneration ability for this kind of injury, serving as biocompatible structures for cell viability and differentiation. Since biomechanical cues such as substrate stiffness, loading conditions and fluid permeation are fundamental for successful tissue repair, understanding how these features vary in the scaffold is of primary importance. Here we present a mathematical model based on porous media mechanics for the analysis of a tissue engineering scaffold. We consider a threelayered scaffold mimicking a complete osteochondral tissue and vary the mechanical properties of the intermediate layer over a physiological range. Our results show that the interstitial fluid pressure and the vertical component of the solid effective stress depend significantly on the stiffness and permeability of the intermediate layer under mechanical loading. By properly tuning these material properties, regimes of slow or fast temporal variations of mechanical stress can be obtained in the scaffold layer of interest.

Poro-mechanical analysis of a biomimetic scaffold for osteochondral defects / Mascheroni, Pietro; Grillo, Alfio; Boso, Daniela P. - STAMPA. - (2020), pp. 606-626. (Intervento presentato al convegno AIMETA 2019 XXIV Conference of the Italian Association of Theoretical and Applied Mechanics tenutosi a Rome, Italy nel 15-19 settembre 2019) [10.1007/978-3-030-41057-5].

Poro-mechanical analysis of a biomimetic scaffold for osteochondral defects

Grillo, Alfio;
2020

Abstract

Osteochondral defects are focal areas of damage involving articular cartilage and sub-chondral bone. Tissue engineering scaffolds are used to improve the organism regeneration ability for this kind of injury, serving as biocompatible structures for cell viability and differentiation. Since biomechanical cues such as substrate stiffness, loading conditions and fluid permeation are fundamental for successful tissue repair, understanding how these features vary in the scaffold is of primary importance. Here we present a mathematical model based on porous media mechanics for the analysis of a tissue engineering scaffold. We consider a threelayered scaffold mimicking a complete osteochondral tissue and vary the mechanical properties of the intermediate layer over a physiological range. Our results show that the interstitial fluid pressure and the vertical component of the solid effective stress depend significantly on the stiffness and permeability of the intermediate layer under mechanical loading. By properly tuning these material properties, regimes of slow or fast temporal variations of mechanical stress can be obtained in the scaffold layer of interest.
2020
978-3-030-41057-5
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11583/2863601