In this work, dense, porous, and, for the first time, functionally-graded bi-layer scaffolds with a cylindrical geometry were produced from a commercially available hydroxyapatite powder using the robocasting technique. The bi-layer scaffolds were made of a dense core part attached to a surrounding porous part. Subsequently, these bi-layer robocast scaffolds were joined with an outer shell of an antibacterial porous polymer layer fabricated by solvent casting/salt leaching techniques, leading to hybrid ceramic-polymer scaffolds. The antibacterial functionality was achieved through the addition of silver ions to the polymer layer. All the robocast samples, including the bi-layer ones, were first characterized through scanning electron microscopy observations, mechanical characterization in compression and preliminary bioactivity tests. Then, the hybrid bi-layer ceramic-polymer scaffolds were characterized through antimicrobial tests. After sintering at 1300 for 3 h, the compressive strengths of the structures were found to be equal to 29 4 MPa for dense samples and 7 4 MPa for lattice structures with a porosity of 34.1%. Bioactivity tests performed at 37 for 4 weeks showed that the precipitated layer on the robocast samples contained octacalcium phosphate. Finally, it was evidenced that the hybrid structure was effective in releasing antibacterial Ag+ ions to the surrounding medium showing its potential efficiency in limiting Staphylococcus aureus proliferation during surgery.
Robocasting of single and multi-functional calcium phosphate scaffolds and its hybridization with conventional techniques: Design, fabrication and characterization / Mohammadi, M.; Pascaud-Mathieu, P.; Allizond, V.; Tulliani, J. M.; Coppola, B.; Banche, G.; Chaput, C.; Cuffini, A. M.; Rossignol, F.; Palmero, P.. - In: APPLIED SCIENCES. - ISSN 2076-3417. - 10:23(2020), pp. 1-22.
|Titolo:||Robocasting of single and multi-functional calcium phosphate scaffolds and its hybridization with conventional techniques: Design, fabrication and characterization|
|Data di pubblicazione:||2020|
|Digital Object Identifier (DOI):||http://dx.doi.org/10.3390/app10238677|
|Appare nelle tipologie:||1.1 Articolo in rivista|