Archivio Istituzionale della RicercaFreeze-drying of a peptide solution is here presented, from the early identification of critical product temperature to the design of an appropriate cycle. Synergy between experimental characterisation techniques, mathematical modelling and process simulation has been implemented to develop a robust lyophilisation process and guarantee the removal of solvents impurities. Process has been carried out in bulk using a tray equipped with an anisotropic membrane, enabling unidirectional vapour flow.
Development of freeze-drying cycle for a peptide-based drug in trays / Artusio, Fiora; Borgogno, Andrea; Cabri, Walter; Ricci, Antonio; Udrescu, Claudia; Viola, Angelo; Pisano, Roberto. - ELETTRONICO. - (2019), pp. 442-449. (Intervento presentato al convegno 7th European Drying Conference tenutosi a Torino nel 10-12 luglio 2019).
Development of freeze-drying cycle for a peptide-based drug in trays
Artusio, Fiora;Udrescu, Claudia;Pisano, Roberto
2019
Abstract
Freeze-drying of a peptide solution is here presented, from the early identification of critical product temperature to the design of an appropriate cycle. Synergy between experimental characterisation techniques, mathematical modelling and process simulation has been implemented to develop a robust lyophilisation process and guarantee the removal of solvents impurities. Process has been carried out in bulk using a tray equipped with an anisotropic membrane, enabling unidirectional vapour flow.
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2019-Eurodrying-2019-Proceeding-(editorial-version).pdf
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Descrizione: 2019-Eurodrying-2019-Proceeding-(editorial-version)
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https://hdl.handle.net/11583/2854182