Archivio Istituzionale della RicercaAlzheimer’s disease is investigated using a thermodynamic approach based on ion fluxes across the neuronal membrane. Our study indicates that the onset of Alzheimer’s may be aided by a hyperpolarization of this membrane, because hyperpolarization-activated cyclic nucleotide gated HCN channels 1–4 conduct inward, with the consequence of depolarising Na+/K+ currents which in turn impacts synaptic transmission and reduces plasticity.
Alzheimer’s Disease: A Thermodynamic Perspective / Lucia, U.; Grisolia, G.; Deisboeck, T. S.. - In: APPLIED SCIENCES. - ISSN 2076-3417. - STAMPA. - 10:(2020), pp. 7562-7571. [10.3390/app10217562]
Alzheimer’s Disease: A Thermodynamic Perspective
Lucia, U.;Grisolia, G.;
2020
Abstract
Alzheimer’s disease is investigated using a thermodynamic approach based on ion fluxes across the neuronal membrane. Our study indicates that the onset of Alzheimer’s may be aided by a hyperpolarization of this membrane, because hyperpolarization-activated cyclic nucleotide gated HCN channels 1–4 conduct inward, with the consequence of depolarising Na+/K+ currents which in turn impacts synaptic transmission and reduces plasticity.
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https://hdl.handle.net/11583/2850173