Temperature monitoring of tumor hyperthermal treatments with optical fibers: comparison of distributed and quasi-distributed techniques

Optical fiber based sensors capable of measuring temperature distribution over a given length are particularly at- tractive in the biomedical field, especially in the case of real-time monitoring of minimally invasive hyperthermal treatments of tumors, such as laser ablation, given their intrinsic multiplexing along a single fiber span and the unique properties of optical fibers in terms of flexibility, size and electromagnetic compatibility. The paper com- pares two sensing approaches: one is based on an array of Bragg gratings inscribed in the core of a single-mode fiber, the other detects Rayleigh backscattering from an unmodified single-mode fiber using coherent optical frequency domain reflectometry. Following an introduction, which describes the most distinctive features of the two approaches, the paper presents three comparative experiments, each devised to highlight a peculiar aspect of the sensors. In the first experiment the sensors are exposed to various constant temperature distributions to evaluate the uniformity of the readings along the fiber length. In the second experiment, a known temperature profile is generated through an ad hoc setup to evaluate the actual capability of the two approaches to reconstruct the tem- perature distribution. Finally, in the third experiment the two sensors are employed in a simulated tumor laser ablation procedure to measure the temperature distribution in the irradiated area. Both sensors provide results whose error, mainly due to cross sensitivity between temperature and strain, is acceptable for the considered biomedical application.