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EnglishOver the recent years, nanometric hydroxyapatite (HA) has gained interest as constituent of hybrid systems for bone scaffold fabrication, due to its biomimicry and biocompatibility. In this study, rod-like nano-HA particles were introduced in a type I collagen matrix to create a composite mimicking the bone composition. HA nanorods (40−60 nm ×20 nm) were synthesised by hydrothermal method involving the use of an ammonium-based dispersing agent (Darvan 821-A) and fully characterised. The homogeneous dispersion of HA nanoparticles throughout the final hybrid formulation was achieved through their suspension in a collagen solution in presence of Darvan 821-A. The resulting homogeneous collagen/nano-HA suspension proved to be suitable for extrusion printing applications, showing shear thinning and sol-gel transition upon simil-physiological conditions. Furthermore, mesh-like structures were printed in a gelatine-supporting bath by means of a commercial bioprinter further demonstrating the potential of the designed hybrid system for the fabrication of 3D bone-like scaffolds.
Synthesis and incorporation of rod-like nano-hydroxyapatite into type I collagen matrix: a hybrid formulation for 3D printing of bone scaffolds / MONTALBANO, GIORGIA; MOLINO, GIULIA; FIORILLI, SONIA LUCIA; VITALE BROVARONE, CHIARA. - In: JOURNAL OF THE EUROPEAN CERAMIC SOCIETY. - ISSN 0955-2219. - ELETTRONICO. - (2020).
| Titolo: | Synthesis and incorporation of rod-like nano-hydroxyapatite into type I collagen matrix: a hybrid formulation for 3D printing of bone scaffolds |
| Autori: | |
| Data di pubblicazione: | 2020 |
| Rivista: | |
| Digital Object Identifier (DOI): | http://dx.doi.org/10.1016/j.jeurceramsoc.2020.02.018 |
| Appare nelle tipologie: | 1.1 Articolo in rivista |
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| File | Descrizione | Tipologia | Licenza | |
|---|---|---|---|---|
| Synthesis and incorporation of rod-like nano-hydroxyapatite into type I collagen matrix_a hybrid formulation for 3d printing of bone scaffolds.pdf | Articolo principale | 2a Post-print versione editoriale / Version of Record |  | Visibile a tuttiVisualizza/Apri |
http://hdl.handle.net/11583/2804823
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