Textiles lie at the interface between human body and the environment and cover the majority of body surface for most of the day. Skin surface can be as large as 2 m2 and it is a potential route for drug delivery. This simple observation suggests that textiles can be used as comfortable systems for delivering active principles/drugs either towards the body or the surrounding environment. On the one hand, fibres are perfect for being used as substrate for drug delivery thanks to great surface-to volume ratio but, on the other hand, the role of the textile substrate on drug release has been so far neglected: for instance, even though the type of weaving or knitting pattern alters surface topography and number of fabric-to-skin contact points, few works have been dedicated to understanding how fabric structure determines drug loading and, most importantly, drug release. Based on the experience carried out in Politecnico di Torino laboratories, the talk will focus on the processes for fabric functionalization with active principles, the mechanisms of controlled release from textiles and fibres (based on desorption from the fibre surface, diffusion from the fibres pores or degradation of the matrix) and the different release kinetics models. The talk will report about challenges and opportunities for textile materials to become active systems for improving health and protection by conferring textiles new functionalities through surface modification.

Molecules to wear: use of functionalized textiles for drug delivery / Ferri, A. - ELETTRONICO. - (2019). (Intervento presentato al convegno Textile Chemistry: Traditions and innovations tenutosi a Ivanovo (Russia) nel 2-4 Aprile).

Molecules to wear: use of functionalized textiles for drug delivery

Ferri A
2019

Abstract

Textiles lie at the interface between human body and the environment and cover the majority of body surface for most of the day. Skin surface can be as large as 2 m2 and it is a potential route for drug delivery. This simple observation suggests that textiles can be used as comfortable systems for delivering active principles/drugs either towards the body or the surrounding environment. On the one hand, fibres are perfect for being used as substrate for drug delivery thanks to great surface-to volume ratio but, on the other hand, the role of the textile substrate on drug release has been so far neglected: for instance, even though the type of weaving or knitting pattern alters surface topography and number of fabric-to-skin contact points, few works have been dedicated to understanding how fabric structure determines drug loading and, most importantly, drug release. Based on the experience carried out in Politecnico di Torino laboratories, the talk will focus on the processes for fabric functionalization with active principles, the mechanisms of controlled release from textiles and fibres (based on desorption from the fibre surface, diffusion from the fibres pores or degradation of the matrix) and the different release kinetics models. The talk will report about challenges and opportunities for textile materials to become active systems for improving health and protection by conferring textiles new functionalities through surface modification.
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11583/2749957
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