Recently, magnetic nanostructures (MNs) have been intensively studied for future application in cancer treatment, thanks to the possibility of inducing cell apoptosis via hyperthermia or cell membrane mechanical stimulation [1]. Focusing on hyperthermia, when an external ac magnetic field is applied to an ensemble of MNs dispersed in a tissue, different physical phenomena can concur to heat generation, e.g. Néel relaxation, Brownian relaxation, hysteresis and eddy current losses, with relative contribution strongly dependent on the size and physical properties of MNs. Here, we present a micromagnetic modelling analysis of permalloy MNs with variable shape (disk, ring, cube, pillar, sphere), for possible application in magnetically mediated hyperthermia. A parametric study is performed by varying aspect ratio and size (up to 1 μm), with the aim of finding the optimal conditions for the maximization of the specific heating capabilities. Hysteresis losses, being the predominant heating contribution for the considered MNs, are calculated by means of a 3D GPU-parallelized micromagnetic code, implementing an FFT approach for the magnetostatic field evaluation and a Cayley transform based scheme for the time integration. The numerical results are validated by comparison to experimental data, obtained for the specific case of permalloy nanodisks (diameter from 200 nm to 650 nm), prepared via polystyrene nanosphere self-assembling.

Parametric analysis of magnetic nanostructures for hyperthermia applications / Ferrero, R.; Manzin, A.; Barrera, G.; Celegato, F.; Coïsson, M.; Tiberto, P.. - (2018). ((Intervento presentato al convegno 9th Joint European Magnetic Symposia Conference 2018 tenutosi a Mainz (Germania) nel 3/9/2018-7/9/2018.

Parametric analysis of magnetic nanostructures for hyperthermia applications

R. Ferrero;
2018

Abstract

Recently, magnetic nanostructures (MNs) have been intensively studied for future application in cancer treatment, thanks to the possibility of inducing cell apoptosis via hyperthermia or cell membrane mechanical stimulation [1]. Focusing on hyperthermia, when an external ac magnetic field is applied to an ensemble of MNs dispersed in a tissue, different physical phenomena can concur to heat generation, e.g. Néel relaxation, Brownian relaxation, hysteresis and eddy current losses, with relative contribution strongly dependent on the size and physical properties of MNs. Here, we present a micromagnetic modelling analysis of permalloy MNs with variable shape (disk, ring, cube, pillar, sphere), for possible application in magnetically mediated hyperthermia. A parametric study is performed by varying aspect ratio and size (up to 1 μm), with the aim of finding the optimal conditions for the maximization of the specific heating capabilities. Hysteresis losses, being the predominant heating contribution for the considered MNs, are calculated by means of a 3D GPU-parallelized micromagnetic code, implementing an FFT approach for the magnetostatic field evaluation and a Cayley transform based scheme for the time integration. The numerical results are validated by comparison to experimental data, obtained for the specific case of permalloy nanodisks (diameter from 200 nm to 650 nm), prepared via polystyrene nanosphere self-assembling.
File in questo prodotto:
File Dimensione Formato  
Jems_Abstract.docx

accesso aperto

Tipologia: Abstract
Licenza: PUBBLICO - Tutti i diritti riservati
Dimensione 15.06 kB
Formato Microsoft Word XML
15.06 kB Microsoft Word XML Visualizza/Apri
Pubblicazioni consigliate

Caricamento pubblicazioni consigliate

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/11583/2713807
 Attenzione

Attenzione! I dati visualizzati non sono stati sottoposti a validazione da parte dell'ateneo