The present work focuses on the integration of analytical and numerical strategies to investigate the thermal distribution of cancerous breasts. Coupled stationary bioheat transfer equations are considered for the glandular and heterogeneous tumor regions, which are characterized by different thermophysical properties. The cross-section of the cancerous breast is identified by a homogeneous glandular tissue that surrounds the heterogeneous tumor tissue, which is assumed to be a two-phase periodic composite with non-overlapping circular inclusions and a square lattice distribution, wherein the constituents exhibit isotropic thermal conductivity behavior. Asymptotic periodic homogenization method is used to find the effective properties in the heterogeneous region. The tissue effective thermal conductivities are computed analytically and then used in the homogenized model, which is solved numerically. Results are compared with appropriate experimental data reported in the literature. In particular, the tissue scale temperature profile agrees with experimental observations. Moreover, as a novelty result we find that the tumor volume fraction in the heterogeneous zone influences the breast surface temperature.
The role of malignant tissue on the thermal distribution of cancerous breast / Ramírez-Torres, Ariel; Rodríguez-Ramos, Reinaldo; Sabina, Federico J.; García-Reimbert, Catherine; Penta, Raimondo; Merodio, José; Guinovart-Díaz, Raúl; Bravo-Castillero, Julián; Conci, Aura; Preziosi, Luigi. - In: JOURNAL OF THEORETICAL BIOLOGY. - ISSN 0022-5193. - STAMPA. - 426(2017), pp. 1339-1351.
|Titolo:||The role of malignant tissue on the thermal distribution of cancerous breast|
|Data di pubblicazione:||2017|
|Digital Object Identifier (DOI):||http://dx.doi.org/10.1016/j.jtbi.2017.05.031|
|Appare nelle tipologie:||1.1 Articolo in rivista|
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