Gene expression is a noisy process and several mechanisms, both transcriptional and post- transcriptional, can stabilize protein levels in cells. Much work has focused on the role of miRNAs, showing in particular that miRNA-mediated regulation can bu er expression noise for lowly expressed genes. Here, using in silico simulations and mathematical modeling, we demonstrate that miRNAs can exert a much broader in uence on protein levels by orchestrating competition-induced crosstalk between mRNAs. Most notably, we nd that miRNA-mediated cross-talk (i) can stabilize protein levels across the full range of gene expression rates, and (ii) modi es the correlation pattern of co-regulated interacting proteins, changing the sign of correlations from negative to positive. The latter feature may constitute a potentially robust signature of the existence of RNA crosstalk induced by endogenous competition for miRNAs in standard cellular conditions.
CeRNA crosstalk stabilizes protein expression and affects the correlation pattern of interacting proteins / Martirosyan, Araks; De Martino, Andrea; Pagnani, Andrea; Marinari, Enzo. - In: SCIENTIFIC REPORTS. - ISSN 2045-2322. - 7(2017), p. 43673.
|Titolo:||CeRNA crosstalk stabilizes protein expression and affects the correlation pattern of interacting proteins|
|Data di pubblicazione:||2017|
|Digital Object Identifier (DOI):||http://dx.doi.org/10.1038/srep43673|
|Appare nelle tipologie:||1.1 Articolo in rivista|