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EnglishIn a freeze-drying process for pharmaceuticals it is necessary to monitor product temperature and to identify the ending point of the ice sublimation stage. Besides, it can be worthwhile estimating the heat and mass transfer coefficients, in such a way that a mathematical model can be used to optimize in-line (or off-line, in a successive run) the process. Both results can be achieved using the temperature measurement. In this paper three different approaches are presented, namely (i) the simple use of the temperature measure, (ii) the combination of the temperature measure with a model of the process, and (iii) a soft-sensor. The strengths and drawbacks of the different approaches are discussed, with particular emphasis on the real-time monitoring of the process.
On the use of temperature measurement to monitor a freeze-drying process for pharmaceuticals. / Fissore, Davide; Pisano, Roberto; Barresi, Antonello. - ELETTRONICO. - (2017), pp. 1276-1281. ((Intervento presentato al convegno IEEE International Instrumentation and Measurements Technology Conference “I2MTC 2017” tenutosi a Torino nel 22-25 May.
| Titolo: | On the use of temperature measurement to monitor a freeze-drying process for pharmaceuticals. |
| Autori: | |
| Data di pubblicazione: | 2017 |
| Serie: | |
| Abstract: | In a freeze-drying process for pharmaceuticals it is necessary to monitor product temperature and... to identify the ending point of the ice sublimation stage. Besides, it can be worthwhile estimating the heat and mass transfer coefficients, in such a way that a mathematical model can be used to optimize in-line (or off-line, in a successive run) the process. Both results can be achieved using the temperature measurement. In this paper three different approaches are presented, namely (i) the simple use of the temperature measure, (ii) the combination of the temperature measure with a model of the process, and (iii) a soft-sensor. The strengths and drawbacks of the different approaches are discussed, with particular emphasis on the real-time monitoring of the process. |
| ISBN: | 978-1-5090-3596-0 |
| Appare nelle tipologie: | 4.1 Contributo in Atti di convegno |
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| File | Descrizione | Tipologia | Licenza | |
|---|---|---|---|---|
| 2017_I2MTC_Temperature_07969890.pdf | 2. Post-print / Author's Accepted Manuscript | Non Pubblico - Accesso privato/ristretto | Administrator Richiedi una copia | |
| 2017_I2MTC_Temperature_07969890_cover.pdf | pdf editoriale con cover e pagina ISBN | 2a Post-print versione editoriale / Version of Record | Non Pubblico - Accesso privato/ristretto | Administrator Richiedi una copia |
| 2017_I2MTC_coverpage.pdf | cover page atti | Altro materiale allegato | Non Pubblico - Accesso privato/ristretto | Administrator Richiedi una copia |
http://hdl.handle.net/11583/2671647
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