Characterizing the cardiovascular functions during atrial fibrillation through lumped-parameter modeling

Atrial fibrillation (AF), causing irregular and rapid heartbeats, is the most common arrhythmia. Due to the widespread impact on the population and the disabling symptoms related to rapid heart rate, AF is a subject of growing interest under several aspects: statistical analyses on the heartbeat distributions, risk factors, impact on quality of life, correlation with other cardiac pathologies. However, several key points on the consequences induced by AF on the cardiovascular system are still not completely understood. The proposed work aims at quantifying the impact of AF on the most relevant cardiovascular parameters by means of a lumped-parameter modeling, paying particular attention to the stochastic nature of the irregular heartbeats and the reduced contractility of the heart. The global response leads to a rather impressive overall agreement with the clinical state-of-the-art measures regarding AF: reduced cardiac output with correlated arterial hypotension, as well as higher left atrial volume and pressure values are some of the most representative outcomes emerging during AF. Moreover, new insights on hemodynamic parameters such as cardiac flow rates, which are difficult to measure and almost never offered in literature, are here provided.