Long-term cerebrovascular reactivity mediatedby ozone autohemotherapy: a NIRS study

Ozone autohemotherapy is an emerging therapeutic technique. A validated and standard methodology to assess the effect of such therapy is still lacking. We used a nearinfrared spectroscopy system (NIRS) to monitor the cerebral oxygenation of 8 subjects (6 neurological) before, during, and after ozone autohemotherapy. The oxygen concentration in brain tissue markedly increased about 1-2 hours after therapy. The time-frequency analysis of the NIRS signals revealed an increasing activity in the LF frequency band related to the vascular autoregulation. This preliminary study showed that NIRS could be useful to show the effects of ozone autohemotherapy at cerebral level, in a long term monitoring.