The authors address the problem of downhill protein folding in the framework of a simple statistical mechanical model, which allows an exact solution for the equilibrium and a semianalytical treatment of the kinetics. Focusing on protein 1BBL, a candidate for downhill folding behavior, and comparing it to the WW domain of protein PIN1, a two-state folder of comparable size, the authors show that there are qualitative differences in both the equilibrium and kinetic properties of the two molecules. However, the barrierless scenario which would be expected if 1BBL were a true downhill folder is observed only at low enough temperature.

Downhill versus two-state protein folding in a statistical mechanical model / Bruscolini, P; Pelizzola, Alessandro; Zamparo, Marco. - In: THE JOURNAL OF CHEMICAL PHYSICS. - ISSN 0021-9606. - 126:(2007), pp. 215103-1-215103-8. [10.1063/1.2738473]

Downhill versus two-state protein folding in a statistical mechanical model

PELIZZOLA, ALESSANDRO;ZAMPARO, MARCO
2007

Abstract

The authors address the problem of downhill protein folding in the framework of a simple statistical mechanical model, which allows an exact solution for the equilibrium and a semianalytical treatment of the kinetics. Focusing on protein 1BBL, a candidate for downhill folding behavior, and comparing it to the WW domain of protein PIN1, a two-state folder of comparable size, the authors show that there are qualitative differences in both the equilibrium and kinetic properties of the two molecules. However, the barrierless scenario which would be expected if 1BBL were a true downhill folder is observed only at low enough temperature.
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11583/1630979
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