Heart diseases (HDs) represent a major health challenge, being the leading cause of mortality and morbidity worldwide.1 HDs impose a huge economic burden to the healthcare system and the whole society, which is expected to increase due to the growth and aging of the population.2 Hence, safe and effective therapies for HD treatment are highly demanded. However, their development has been mostly limited by pre-clinical testing in poorly predictive in vitro 2D cell cultures and in vivo animal models affected by interspecies differences.3 Limitations in pre-clinical testing also impose safety risks for patients involved in the next clinical trials, which may include impaired cardiac function at different levels up to fatal arrhythmias, ischaemic events, myocardial infarction, and injuries to cardiac valves, the conduction system and the pericardium. In other cases, patient-specific cardiotoxicity risks have been detected only after drug approval causing their withdrawal from the market.4 Notably, drugs developed for other purposes than HD treatment (e.g. chemotherapeutics) also need early cardiotoxicity risk assessment as they may have adverse effects on the heart.

European Research Council-funded grant: development of a novel cardiac tissue model / Ruocco, Gerardina; Testore, Daniele; Chiono, Valeria.. - In: EUROPEAN HEART JOURNAL. - ISSN 1522-9645. - ELETTRONICO. - 46:3(2025), pp. 233-235. [10.1093/eurheartj/ehae740]

European Research Council-funded grant: development of a novel cardiac tissue model

Ruocco, Gerardina;Testore, Daniele;Chiono, Valeria.
2025

Abstract

Heart diseases (HDs) represent a major health challenge, being the leading cause of mortality and morbidity worldwide.1 HDs impose a huge economic burden to the healthcare system and the whole society, which is expected to increase due to the growth and aging of the population.2 Hence, safe and effective therapies for HD treatment are highly demanded. However, their development has been mostly limited by pre-clinical testing in poorly predictive in vitro 2D cell cultures and in vivo animal models affected by interspecies differences.3 Limitations in pre-clinical testing also impose safety risks for patients involved in the next clinical trials, which may include impaired cardiac function at different levels up to fatal arrhythmias, ischaemic events, myocardial infarction, and injuries to cardiac valves, the conduction system and the pericardium. In other cases, patient-specific cardiotoxicity risks have been detected only after drug approval causing their withdrawal from the market.4 Notably, drugs developed for other purposes than HD treatment (e.g. chemotherapeutics) also need early cardiotoxicity risk assessment as they may have adverse effects on the heart.
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11583/2995362