A Statistical Mechanics Approach to Describe Cell Reorientation Under Stretch

Experiments show that when a monolayer of cells cultured on an elastic substratum is subject to a cyclic stretch, cells tend to reorient either perpendicularly or at an oblique angle with respect to the main stretching direction. Due to stochastic effects, however, the distribution of angles achieved by the cells is broader and, experimentally, histograms over the interval [0(?), 90(?)] are usually reported. Here we will determine the evolution and the stationary state of probability density functions describing the statistical distribution of the orientations of the cells using Fokker-Planck equations derived from microscopic rules for describing the reorientation process of the cell. As a first attempt, we shall use a stochastic differential equation related to a very general elastic energy that the cell tries to minimize and, we will show that the results of the time integration and of the stationary state of the related forward Fokker-Planck equation compare very well with experimental results obtained by different researchers. Then, in order to model more accurately the microscopic process of cell reorientation and to shed light on the mechanisms performed by cells that are subject to cyclic stretch, we consider discrete in time random processes that allow to recover Fokker-Planck equations through classical tools of kinetic theory. In particular, we shall introduce a model of reorientation as a function of the rotation angle as a result of an optimal control problem. Also in this latter case the results match very well with experiments.