Archivio Istituzionale della RicercaBioprocessing steps of parentals traditionally involve large velocity gradients. These gradients result in high shear stresses, generally believed to affect product stability. Precise modelling of unit operations is therefore necessary to quantify the sources of shear. Here, CFD analysis was applied to flow through tubing and fittings under laminar and turbulent conditions; equations were proposed to assess the average shear experienced by the product.
Analysis of the shear stresses in a filling line of parental products: the role of tubing and fittings / Moino, Camilla; Scutellà, Bernadette; Bellini, Marco; Bourlès, Erwan; Boccardo, Gianluca; Pisano, Roberto. - ELETTRONICO. - (2022), pp. 1-1. (Intervento presentato al convegno 13th World Meeting on Pharmaceutics, Biopharmaceutics and Pharmaceutical Technology).
Analysis of the shear stresses in a filling line of parental products: the role of tubing and fittings
Camilla Moino;Gianluca Boccardo;Roberto Pisano
2022
Abstract
Bioprocessing steps of parentals traditionally involve large velocity gradients. These gradients result in high shear stresses, generally believed to affect product stability. Precise modelling of unit operations is therefore necessary to quantify the sources of shear. Here, CFD analysis was applied to flow through tubing and fittings under laminar and turbulent conditions; equations were proposed to assess the average shear experienced by the product.
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https://hdl.handle.net/11583/2961698