Many disorders block and subvert basic cellular processes in order to boost their pro-gression. One protein family that is prone to be altered in human cancers is the small GTPase RAB11 family, the master regulator of vesicular trafficking. RAB11 isoforms function as membrane organizers connecting the transport of cargoes towards the plasma membrane with the assembly of autophagic precursors and the generation of cellular protrusions. These processes dramatically impact normal cell physiology and their alteration significantly affects the survival, progression and metastatization as well as the accumulation of toxic materials of cancer cells. In this review, we dis-cuss biological mechanisms ensuring cargo recognition and sorting through a RAB11-dependent pathway, a prerequisite to understand the effect of RAB11 alterations in human cancers.

Rab11-mediated trafficking and human cancers: An updated review / Ferro, E.; Bosia, C.; Campa, C. C.. - In: BIOLOGY. - ISSN 2079-7737. - ELETTRONICO. - 10:1(2021), pp. 1-15. [10.3390/biology10010026]

Rab11-mediated trafficking and human cancers: An updated review

Ferro E.;Bosia C.;Campa C. C.
2021

Abstract

Many disorders block and subvert basic cellular processes in order to boost their pro-gression. One protein family that is prone to be altered in human cancers is the small GTPase RAB11 family, the master regulator of vesicular trafficking. RAB11 isoforms function as membrane organizers connecting the transport of cargoes towards the plasma membrane with the assembly of autophagic precursors and the generation of cellular protrusions. These processes dramatically impact normal cell physiology and their alteration significantly affects the survival, progression and metastatization as well as the accumulation of toxic materials of cancer cells. In this review, we dis-cuss biological mechanisms ensuring cargo recognition and sorting through a RAB11-dependent pathway, a prerequisite to understand the effect of RAB11 alterations in human cancers.
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Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/11583/2875672