We designed liposomes dually functionalized with ApoE-derived peptide (mApoE) and chlorotoxin (ClTx) to improve their blood-brain barrier (BBB) crossing. Our results demonstrated the synergistic activity of ClTx-mApoE in boosting doxorubicin-loaded liposomes across the BBB, keeping the anti-tumour activity of the drug loaded: mApoE acts promoting cellular uptake, while ClTx promotes exocytosis of liposomes.

The synergistic effect of chlorotoxin-mApoE in boosting drug-loaded liposomes across the BBB / Formicola, B.; Dal Magro, R.; Montefusco-Pereira, C. V.; Lehr, C. -M.; Koch, M.; Russo, L.; Grasso, G.; Deriu, M. A.; Danani, A.; Bourdoulous, S.; Re, F.. - In: JOURNAL OF NANOBIOTECHNOLOGY. - ISSN 1477-3155. - 17:1(2019), p. 115. [10.1186/s12951-019-0546-3]

The synergistic effect of chlorotoxin-mApoE in boosting drug-loaded liposomes across the BBB

Deriu M. A.;
2019

Abstract

We designed liposomes dually functionalized with ApoE-derived peptide (mApoE) and chlorotoxin (ClTx) to improve their blood-brain barrier (BBB) crossing. Our results demonstrated the synergistic activity of ClTx-mApoE in boosting doxorubicin-loaded liposomes across the BBB, keeping the anti-tumour activity of the drug loaded: mApoE acts promoting cellular uptake, while ClTx promotes exocytosis of liposomes.
File in questo prodotto:
File Dimensione Formato  
The synergistic effect of chlorotoxin-mApoE in boosting drug-loaded liposomes across the BBB.pdf

accesso aperto

Tipologia: 2a Post-print versione editoriale / Version of Record
Licenza: Creative commons
Dimensione 1.04 MB
Formato Adobe PDF
1.04 MB Adobe PDF Visualizza/Apri
Pubblicazioni consigliate

Caricamento pubblicazioni consigliate

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/11583/2866000