Archivio Istituzionale della RicercaWe designed liposomes dually functionalized with ApoE-derived peptide (mApoE) and chlorotoxin (ClTx) to improve their blood-brain barrier (BBB) crossing. Our results demonstrated the synergistic activity of ClTx-mApoE in boosting doxorubicin-loaded liposomes across the BBB, keeping the anti-tumour activity of the drug loaded: mApoE acts promoting cellular uptake, while ClTx promotes exocytosis of liposomes.
The synergistic effect of chlorotoxin-mApoE in boosting drug-loaded liposomes across the BBB / Formicola, B.; Dal Magro, R.; Montefusco-Pereira, C. V.; Lehr, C. -M.; Koch, M.; Russo, L.; Grasso, G.; Deriu, M. A.; Danani, A.; Bourdoulous, S.; Re, F.. - In: JOURNAL OF NANOBIOTECHNOLOGY. - ISSN 1477-3155. - 17:1(2019), p. 115. [10.1186/s12951-019-0546-3]
The synergistic effect of chlorotoxin-mApoE in boosting drug-loaded liposomes across the BBB
Deriu M. A.;
2019
Abstract
We designed liposomes dually functionalized with ApoE-derived peptide (mApoE) and chlorotoxin (ClTx) to improve their blood-brain barrier (BBB) crossing. Our results demonstrated the synergistic activity of ClTx-mApoE in boosting doxorubicin-loaded liposomes across the BBB, keeping the anti-tumour activity of the drug loaded: mApoE acts promoting cellular uptake, while ClTx promotes exocytosis of liposomes.
| File | Dimensione | Formato | |
|---|---|---|---|
|
The synergistic effect of chlorotoxin-mApoE in boosting drug-loaded liposomes across the BBB.pdf
accesso aperto
Tipologia:
2a Post-print versione editoriale / Version of Record
Licenza:
Creative commons
Dimensione
1.04 MB
Formato
Adobe PDF
|
1.04 MB | Adobe PDF | Visualizza/Apri |
Pubblicazioni consigliate
I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
https://hdl.handle.net/11583/2866000