Archivio Istituzionale della RicercaWe designed liposomes dually functionalized with ApoE-derived peptide (mApoE) and chlorotoxin (ClTx) to improve their blood-brain barrier (BBB) crossing. Our results demonstrated the synergistic activity of ClTx-mApoE in boosting doxorubicin-loaded liposomes across the BBB, keeping the anti-tumour activity of the drug loaded: mApoE acts promoting cellular uptake, while ClTx promotes exocytosis of liposomes.
The synergistic effect of chlorotoxin-mApoE in boosting drug-loaded liposomes across the BBB / Formicola, B., Dal Magro, R., Montefusco-Pereira, C.V., Lehr, C.-M., Koch, M., Russo, L., Grasso, G., Deriu, M.A., Danani, A., Bourdoulous, S., Re, F.. - In: JOURNAL OF NANOBIOTECHNOLOGY. - ISSN 1477-3155. - 17:1(2019), p. 115. [10.1186/s12951-019-0546-3]
The synergistic effect of chlorotoxin-mApoE in boosting drug-loaded liposomes across the BBB
Deriu M. A.;
2019
Abstract
We designed liposomes dually functionalized with ApoE-derived peptide (mApoE) and chlorotoxin (ClTx) to improve their blood-brain barrier (BBB) crossing. Our results demonstrated the synergistic activity of ClTx-mApoE in boosting doxorubicin-loaded liposomes across the BBB, keeping the anti-tumour activity of the drug loaded: mApoE acts promoting cellular uptake, while ClTx promotes exocytosis of liposomes.
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The synergistic effect of chlorotoxin-mApoE in boosting drug-loaded liposomes across the BBB.pdf
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https://hdl.handle.net/11583/2866000