Purpose To show some preliminary results about the possibility to exploit a cardiovascular mathematical model—made patient-specific by noninvasive data routinely measured during ordinary clinical examinations—in order to obtain sufficiently accurate central blood pressure (BP) estimates. Methods A closed-loop multiscale (0D and 1D) model of the cardiovascular system is made patient-specific by using as model inputs the individual mean heart rate and left-ventricular contraction time, weight, height, age, sex and mean/pulse brachial BPs. The resulting framework is used to determine central systolic, diastolic, mean and pulse pressures, which are compared with the beat-averaged invasive pressures of 12 patients aged 72 ± 6.61 years. Results Errors in central systolic, diastolic, mean and pulse pressures by the model are 4.26 ± 2.81, 5.86 ± 4.38, 4.98 ± 3.95 and 3.51±2.38 mmHg, respectively. Conclusion The proposed modeling approach shows a good patient-specific response and appears to be potentially useful in clinical practice. However, this approach needs to be evaluated in a larger cohort of patients and could possibly be improved through more accurate oscillometric BP measurement methods.
Testing a Patient-Specific In-Silico Model to Noninvasively Estimate Central Blood Pressure / Gallo, Caterina; Olbers, Joakim; Ridolfi, Luca; Scarsoglio, Stefania; Witt, Nils. - In: CARDIOVASCULAR ENGINEERING AND TECHNOLOGY. - ISSN 1869-408X. - ELETTRONICO. - (2021). [10.1007/s13239-020-00512-9]
|Titolo:||Testing a Patient-Specific In-Silico Model to Noninvasively Estimate Central Blood Pressure|
|Data di pubblicazione:||2021|
|Digital Object Identifier (DOI):||http://dx.doi.org/10.1007/s13239-020-00512-9|
|Appare nelle tipologie:||1.1 Articolo in rivista|
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