This study covers the preparation of microspheres for the controlled and targeted release of paclitaxel, using novel degradable polymers as carrier materials. Paclitaxel-loaded microspheres were prepared by oil-in-water single-emulsion solvent extraction/evaporation technique by using a series of polyurethanes and a block copolymer; the physicochemical properties of these polymers were modulated by changing nature and composition of their structural units. The obtained microparticles showed a regular morphology and properties (diameter: 1-100μm; resuspension index: 18.8-100%; encapsulation efficiency: 26.6-97.2%) depending on polymer hydrophilicity and emulsifier used. In vitro release curves showed in all cases almost zero-order kinetics after an initial low burst effect (from 1 to 8.4%), which is required to minimize the drug side effects. This work also proposes a novel strategy to combine a controlled and a targeted release through the functionalization of the polymer matrix with peptide sequences. An RGD-functionalized polyurethane was used to successfully prepare paclitaxel-loaded microparticles. Studies on the preparation of polymer microspheres are reported. © 2013 European Peptide Society and John Wiley & Sons, Ltd.
Biodegradable paclitaxel-loaded microparticles prepared from novel block copolymers: Influence of polymer composition on drug encapsulation and release / Sartori, S.; Caporale, A.; Rechichi, A.; Cufari, D.; Cristallini, C.; Barbani, N.; Giusti, P.; Ciardelli, G.. - In: JOURNAL OF PEPTIDE SCIENCE. - ISSN 1075-2617. - 19:4(2013), pp. 205-213. [10.1002/psc.2491]
|Titolo:||Biodegradable paclitaxel-loaded microparticles prepared from novel block copolymers: Influence of polymer composition on drug encapsulation and release|
|Data di pubblicazione:||2013|
|Digital Object Identifier (DOI):||http://dx.doi.org/10.1002/psc.2491|
|Appare nelle tipologie:||1.1 Articolo in rivista|
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