Background: When possible, a single-stent technique to treat coronary bifurcation disease is preferable. However, when 2 stents are required, there is scope to improve on existing techniques. The crush technique has already been improved with the introduction of double-kissing (DK) and minicrush. We sought to refine and simplify the minicrush technique, retaining its advantages while avoiding its disadvantages, by developing a DK nanocrush technique. Methods: The DK nanocrush method allows complete lesion coverage of a bifurcation lesion without excessive metal layers. This is achieved by positioning the side branch (SB) stent with minimal protrusion into the main branch (MB), implantation of the SB stent with an undeployed balloon in the MB, immediate kissing-balloon inflation with formation of a minimal neocarina, stenting the MB, recrossing the proximal part of the SB without crossing a double metal layer, and final kissing. We demonstrate this technique with benchtop implantation, microscopic computed tomographic reconstruction, computational fluid dynamics (CFD) modelling, and clinically with the use of angiographic and intravascular imaging. Results: The DK nanocrush was practically feasible and resulted in full ostial coverage. CFD analysis demonstrated minimally disturbed blood flow. The technique was successfully utilised in 9 patients with bifurcation lesions with excellent angiographic outcomes and no adverse events over 12 months. Conclusions: The DK nanocrush technique may represent the ultimate refinement of the original crush technique with a number of practical and theoretical advantages. It remains to be tested against other bifurcation techniques in prospective trials.
The Double-Kissing Nano-Crush for Bifurcation lesions: Development, Bioengineering, Fluid dynamics and Initial Clinical Testing / Morris, Paul D.; Gosling, Rebecca; Rothman, Alex; Iqbal, Javaid; Chiastra, Claudio; Colombo, Monika; Migliavacca, Francesco; Banning, Amerjeet; Gunn, Julian P.. - In: CANADIAN JOURNAL OF CARDIOLOGY. - ISSN 0828-282X. - ELETTRONICO. - 36:6(2020), pp. 852-859.
|Titolo:||The Double-Kissing Nano-Crush for Bifurcation lesions: Development, Bioengineering, Fluid dynamics and Initial Clinical Testing|
|Data di pubblicazione:||2020|
|Digital Object Identifier (DOI):||http://dx.doi.org/10.1016/j.cjca.2019.08.037|
|Appare nelle tipologie:||1.1 Articolo in rivista|
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