A novel approach for the study of low concentrated DNAs (60 pM) using microRaman spectroscopy is reported. A superhydrophobic substrate with array of microPillars is fabricated over which the sample was drop casted. The substrate concentrates the molecules in a very small area with higher molecular density, enabling to carry out the microRaman measurements. Two different DNAs (single strand and double strand) were used to investigate through Raman technique. A spectral Raman difference was found to distinguish the ssDNA and dsDNAs. The approach can be of interest for a wide variety of applications ranging from biological materials interactions characterization to the biomedical field. © 2014 Elsevier B.V. All rights reserved.
Raman spectroscopy for detection of stretched DNAs on superhydrophobic surfaces / Marini, M.; Das, G.; La Rocca, R.; Gentile, F.; Limongi, T.; Santoriello, S.; Scarpellini, A.; Di Fabrizio, E.. - In: MICROELECTRONIC ENGINEERING. - ISSN 0167-9317. - STAMPA. - 119(2014), pp. 151-154. [10.1016/j.mee.2014.04.008]
|Titolo:||Raman spectroscopy for detection of stretched DNAs on superhydrophobic surfaces|
|Data di pubblicazione:||2014|
|Digital Object Identifier (DOI):||http://dx.doi.org/10.1016/j.mee.2014.04.008|
|Appare nelle tipologie:||1.1 Articolo in rivista|