A novel approach for the study of low concentrated DNAs (60 pM) using microRaman spectroscopy is reported. A superhydrophobic substrate with array of microPillars is fabricated over which the sample was drop casted. The substrate concentrates the molecules in a very small area with higher molecular density, enabling to carry out the microRaman measurements. Two different DNAs (single strand and double strand) were used to investigate through Raman technique. A spectral Raman difference was found to distinguish the ssDNA and dsDNAs. The approach can be of interest for a wide variety of applications ranging from biological materials interactions characterization to the biomedical field. © 2014 Elsevier B.V. All rights reserved.
Raman spectroscopy for detection of stretched DNAs on superhydrophobic surfaces / Marini, M.; Das, G.; La Rocca, R.; Gentile, F.; Limongi, T.; Santoriello, S.; Scarpellini, A.; Di Fabrizio, E.. - In: MICROELECTRONIC ENGINEERING. - ISSN 0167-9317. - STAMPA. - 119(2014), pp. 151-154.
Titolo: | Raman spectroscopy for detection of stretched DNAs on superhydrophobic surfaces |
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Data di pubblicazione: | 2014 |
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Digital Object Identifier (DOI): | http://dx.doi.org/10.1016/j.mee.2014.04.008 |
Appare nelle tipologie: | 1.1 Articolo in rivista |
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http://hdl.handle.net/11583/2851366