Objective: To test a new bipolar electrode for electroporation consisting of a single minimally invasive needle. Methods: A theoretical study was performed by using Comsol Multiphysics® software. The prototypes of electrode have been tested on potatoes and pigs, adopting an irreversible electroporation protocol. Different applied voltages and different geometries of bipolar electrode prototype have been evaluated. Results: Simulations and pre-clinical tests have shown that the volume of ablated area is mainly influenced by applied voltage, while the diameter of the electrode had a lesser impact, making the goal of minimal-invasiveness possible. The conductive pole’s length determined an increase of electroporated volume, while the insulated pole length inversely affects the electroporated volume size and shape; when the insulated pole length decreases, a more regular shape of the electric field is obtained. Moreover, the geometry of the electrode determined a different shape of the electroporated volume. A parenchymal damage in the liver of pigs due to irreversible electroporation protocol was observed. Conclusion: The minimally invasive bipolar electrode is able to treat an electroporated volume of about 10 mm in diameter by using a single-needle electrode. Moreover, the geometry and the electric characteristics can be selected to produce ellipsoidal ablation volumes.
Design and characterization of a minimally invasive bipolar electrode for electroporation / Merola, G.; Fusco, R.; Di Bernardo, E.; D'alessio, V.; Izzo, F.; Granata, V.; Contartese, D.; Cadossi, M.; Audenino, A.; Gallo, G. P.. - In: BIOLOGY. - ISSN 2079-7737. - 9:9(2020), pp. 1-24.
|Titolo:||Design and characterization of a minimally invasive bipolar electrode for electroporation|
|Data di pubblicazione:||2020|
|Digital Object Identifier (DOI):||http://dx.doi.org/10.3390/biology9090303|
|Appare nelle tipologie:||1.1 Articolo in rivista|