Archivio Istituzionale della RicercaCystic fibrosis is characterized by chronic sinopulmonary Pseudomonas aeruginosa (Pa) infection. Badaoui et al. describe a pathway promoting luminal fibronectin deposition and apical activity of β1 integrin. This ectopic complex leads to increased Pa adhesion to the CF epithelium, a mechanism prevented by targeting the GTP exchange factor Vav3.
Vav3 Mediates Pseudomonas aeruginosa Adhesion to the Cystic Fibrosis Airway Epithelium / Badaoui, M.; Zoso, A.; Idris, T.; Bacchetta, M.; Simonin, J.; Lemeille, S.; Wehrle-Haller, B.; Chanson, M.. - In: CELL REPORTS. - ISSN 2211-1247. - ELETTRONICO. - 32:1(2020). [10.1016/j.celrep.2020.107842]
Vav3 Mediates Pseudomonas aeruginosa Adhesion to the Cystic Fibrosis Airway Epithelium
Zoso A.;
2020
Abstract
Cystic fibrosis is characterized by chronic sinopulmonary Pseudomonas aeruginosa (Pa) infection. Badaoui et al. describe a pathway promoting luminal fibronectin deposition and apical activity of β1 integrin. This ectopic complex leads to increased Pa adhesion to the CF epithelium, a mechanism prevented by targeting the GTP exchange factor Vav3.
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https://hdl.handle.net/11583/2845747