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EnglishThe intravaginal route of administration can be exploited to treat local diseases and for systemic delivery. In this work, we developed an alginate/chitosan membrane sufficiently stable in a simulated vaginal fluid and able to dissolve over time at a very slow and linear rate. The membrane demonstrated good mechanical properties both in its swollen and dry form. As a study case, we evaluated the viability of this potential drug delivery system for the treatment of bacterial vaginosis, a common disease affecting women in their reproductive age. Metronidazole was effectively included in the alginate/chitosan membrane and its bactericide effect was demonstrated against Staphylococcus aureus and Gardnerella vaginalis, simultaneously showing good biocompatibility with a cervix epithelial cell line. Since this alginate/chitosan membrane is stable in a simulated vaginal environment, is easy to fabricate and can be used for the controlled release of a model drug, it represents a promising drug delivery system for local intravaginal applications.
Long lasting mucoadhesive membrane based on alginate and chitosan for intravaginal drug delivery / Tentor, F.; Siccardi, G.; Sacco, P.; Demarchi, D.; Marsich, E.; Almdal, K.; Bose Goswami, S.; Boisen, A.. - In: JOURNAL OF MATERIALS SCIENCE. MATERIALS IN MEDICINE. - ISSN 0957-4530. - 31:3(2020), pp. 1-12. [10.1007/s10856-020-6359-y]
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| Titolo: | Long lasting mucoadhesive membrane based on alginate and chitosan for intravaginal drug delivery | |
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| Data di pubblicazione: | 2020 | |
| Rivista: | ||
| Digital Object Identifier (DOI): | http://dx.doi.org/10.1007/s10856-020-6359-y | |
| Appare nelle tipologie: | 1.1 Articolo in rivista |
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| File | Descrizione | Tipologia | Licenza | |
|---|---|---|---|---|
| Tentor et al. - 2020 - Long lasting mucoadhesive membrane based on alginate and chitosan for intravaginal drug delivery-annotated.pdf | Tentor 2020 | 2a Post-print versione editoriale / Version of Record | Non Pubblico - Accesso privato/ristretto | Administrator Richiedi una copia |
http://hdl.handle.net/11583/2844145
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