The intravaginal route of administration can be exploited to treat local diseases and for systemic delivery. In this work, we developed an alginate/chitosan membrane sufficiently stable in a simulated vaginal fluid and able to dissolve over time at a very slow and linear rate. The membrane demonstrated good mechanical properties both in its swollen and dry form. As a study case, we evaluated the viability of this potential drug delivery system for the treatment of bacterial vaginosis, a common disease affecting women in their reproductive age. Metronidazole was effectively included in the alginate/chitosan membrane and its bactericide effect was demonstrated against Staphylococcus aureus and Gardnerella vaginalis, simultaneously showing good biocompatibility with a cervix epithelial cell line. Since this alginate/chitosan membrane is stable in a simulated vaginal environment, is easy to fabricate and can be used for the controlled release of a model drug, it represents a promising drug delivery system for local intravaginal applications.
Long lasting mucoadhesive membrane based on alginate and chitosan for intravaginal drug delivery / Tentor, F.; Siccardi, G.; Sacco, P.; Demarchi, D.; Marsich, E.; Almdal, K.; Bose Goswami, S.; Boisen, A.. - In: JOURNAL OF MATERIALS SCIENCE. MATERIALS IN MEDICINE. - ISSN 0957-4530. - 31:3(2020), pp. 1-12.
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|Titolo:||Long lasting mucoadhesive membrane based on alginate and chitosan for intravaginal drug delivery|
|Data di pubblicazione:||2020|
|Digital Object Identifier (DOI):||http://dx.doi.org/10.1007/s10856-020-6359-y|
|Appare nelle tipologie:||1.1 Articolo in rivista|
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