Archivio Istituzionale della RicercaFor decades, lipid droplets have been considered as the main cellular organelles involved in the fat storage, because of their lipid composition. However, in recent years, some new and totally unexpected roles have been discovered for them: (i) they are active sites for synthesis and storage of inflammatory mediators, and (ii) they are key players in cancer cells and tissues, especially in cancer stem cells. In this review, we summarize the main concepts related to the lipid droplet structure and function and their involvement in inflammatory and cancer processes.
An Overview of Lipid Droplets in Cancer and Cancer Stem Cells / Tirinato, L.; Pagliari, F.; Limongi, T.; Marini, M.; Falqui, A.; Seco, J.; Candeloro, P.; Liberale, C.; Di Fabrizio, E.. - In: STEM CELLS INTERNATIONAL. - ISSN 1687-9678. - 2017:(2017), p. 1656053. [10.1155/2017/1656053]
An Overview of Lipid Droplets in Cancer and Cancer Stem Cells
Limongi T.;Marini M.;Di Fabrizio E.
2017
Abstract
For decades, lipid droplets have been considered as the main cellular organelles involved in the fat storage, because of their lipid composition. However, in recent years, some new and totally unexpected roles have been discovered for them: (i) they are active sites for synthesis and storage of inflammatory mediators, and (ii) they are key players in cancer cells and tissues, especially in cancer stem cells. In this review, we summarize the main concepts related to the lipid droplet structure and function and their involvement in inflammatory and cancer processes.
| File | Dimensione | Formato | |
|---|---|---|---|
|
1656053.pdf
accesso aperto
Tipologia:
2a Post-print versione editoriale / Version of Record
Licenza:
Creative commons
Dimensione
3.37 MB
Formato
Adobe PDF
|
3.37 MB | Adobe PDF | Visualizza/Apri |
Pubblicazioni consigliate
I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
https://hdl.handle.net/11583/2837370