Nanoparticles production in continuous flow devices - Modelling and experimental insights into continuous flow-based processes

In this work, a general overview on nanoparticles formation processes is given from both modelling and experimental points of view. The key mechanisms are presented and identified, despite some of them are still under debate. Experiments investigated the effect of different good solvents, as well as the role played by the presence of active principles, and more detailed confirmations have been found out thanks to modelling efforts. Population balance modelling and computational fluid dynamics simulations got a deeper insight into the mechanisms and the good solvent effects that lead to nanoparticles formation. Simulations results confirm the trends experimentally observed. Future investigations can be carried out by means of classical molecular dynamics, in order to gain a better understanding of the nanoparticle’s formation dynamics.