John Doe, an 81-year-old patient with a significant distal left main (LM) stenosis, was treated using a provisional stenting approach. As part of an European Bifurcation Club (EBC) project, the complete stenting procedure was repeated using computational modelling. First, a tailored three-dimensional (3D) reconstruction of the bifurcation anatomy was created by fusion of multislice computed tomography (CT) imaging and intravascular ultrasound. Second, finite element analysis was employed to deploy and post-dilate the stent virtually within the generated patient-specific anatomical bifurcation model. Finally, blood flow was modelled using computational fluid dynamics. This proof-of-concept study demonstrated the feasibility of such patient-specific simulations for bifurcation stenting and has provided unique insights into the bifurcation anatomy, the technical aspects of LM bifurcation stenting, and the positive impact of adequate post-dilatation on blood flow patterns. Potential clinical applications such as virtual trials and preoperative planning seem feasible but require a thorough clinical validation of the predictive power of these computer simulations.
|Titolo:||Patient-specific computer modelling of coronary bifurcation stenting: The John Doe programme|
|Data di pubblicazione:||2015|
|Digital Object Identifier (DOI):||10.4244/EIJV11SVA8|
|Appare nelle tipologie:||1.1 Articolo in rivista|
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|2015 Mortier Chiastra - Patient-specific computer modeling of coronary bifurcation stenting - John Doe program.pdf||2a. Post-print Versione editoriale||Non Pubblico - Accesso privato/ristretto||Administrator Richiedi una copia|