In Parkinson's disease, motor uctuations (worsening of tremor, bradykinesia, freezing of gait, postural instability) aect up to 70% of patients within 9 years of L-dopa therapy. Nevertheless, the assessment of motor uctuations is dicult in a medical oce, and is commonly based on poorly reliable self-reports. Hence, the use of wearable sensors is desirable. In this preliminary trial, we have investigated bradykinesia and freezing of gait - FOG - symptoms by means of inertial measurement units. To this purpose, we have employed a single smartphone on the patients waist for FOG ex- periment (38 patients), and on patient thigh for LA (93 subjects). Given the sound performance achieved in this trial (AUC=0.97 for FOG and AUC=0.92 for LA), mo- tor uctuations may be estimated in domestic environ- ments. To this end, we plan to perform measures and data processing on SensorTile, a tiny IoT module in- cluding several sensors, a microcontroller, a BlueTooth low-energy interface and microSD card, implementing an electronic diary of motor uctuations, posture and dyskinesia during activity of daily living.
|Titolo:||Home monitoring of motor fluctuations in Parkinson’s disease patients|
|Data di pubblicazione:||2019|
|Digital Object Identifier (DOI):||10.1007/s40860-019-00086-x|
|Appare nelle tipologie:||1.1 Articolo in rivista|
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