Memristive biosensors have demonstrated excellent capabilities for ultrasensitive bio-detection. In this paper, memristive biosensing chips are designed, fabricated, and implemented in a for the first time presented multi-panel on-chip detection for discrete sensing of a target molecule through separate functionalization of individual devices on the same chip. The biosensing scheme is validated by means of labeled (i.e. fluorescence) and label-free (i.e. electrical) characterization methods. This novel memristive multi-panel sensing paradigm paves the way for fast and ultrasensitive point-of-care (PoC) devices allowing the detection of specific targets in complex matrixes where non-specific molecules are present as well, and opening the great potential for the application of memristive phenomena in multiplexed ultrasensitive bio-detection and theranostics.

Multi-Panel, On-Single-Chip Memristive Biosensing / Tzouvadaki, Ioulia; Tuoheti, Abuduwaili; Lorrain, Severine; Quadroni, Manfredo; Doucey, Marie-Agnes; De Micheli, Giovanni; Demarchi, Danilo; Carrara, Sandro. - In: IEEE SENSORS JOURNAL. - ISSN 1530-437X. - 19:14(2019), pp. 5769-5774. [10.1109/JSEN.2019.2904393]

Multi-Panel, On-Single-Chip Memristive Biosensing

Tuoheti, Abuduwaili;Demarchi, Danilo;
2019

Abstract

Memristive biosensors have demonstrated excellent capabilities for ultrasensitive bio-detection. In this paper, memristive biosensing chips are designed, fabricated, and implemented in a for the first time presented multi-panel on-chip detection for discrete sensing of a target molecule through separate functionalization of individual devices on the same chip. The biosensing scheme is validated by means of labeled (i.e. fluorescence) and label-free (i.e. electrical) characterization methods. This novel memristive multi-panel sensing paradigm paves the way for fast and ultrasensitive point-of-care (PoC) devices allowing the detection of specific targets in complex matrixes where non-specific molecules are present as well, and opening the great potential for the application of memristive phenomena in multiplexed ultrasensitive bio-detection and theranostics.
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11583/2736915
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