Multi-Panel, On-Single-Chip Memristive Biosensing

Memristive biosensors have demonstrated excellent capabilities for ultrasensitive bio-detection. In this paper, memristive biosensing chips are designed, fabricated, and implemented in a for the first time presented multi-panel on-chip detection for discrete sensing of a target molecule through separate functionalization of individual devices on the same chip. The biosensing scheme is validated by means of labeled (i.e. fluorescence) and label-free (i.e. electrical) characterization methods. This novel memristive multi-panel sensing paradigm paves the way for fast and ultrasensitive point-of-care (PoC) devices allowing the detection of specific targets in complex matrixes where non-specific molecules are present as well, and opening the great potential for the application of memristive phenomena in multiplexed ultrasensitive bio-detection and theranostics.