A multi-scale approach can be used to simulate the drying behavior of microparticles in packed-bed. Data outcomes from discrete element method (DEM) and computational fluid dynamics (CFD) simulations can be used to estimate some relevant product characteristics, such as the porosity, tortuosity, voids in the bed and permeability which are required by the multi scale model. Data from DEM simulations are presented, with a particular focus on the influence of the model parameters, packing characteristics and inhomogeneities (wall effect and particles segregation); computational costs and scalability are also considered. Data on the properties of packings as modeled at the macroscale are presented with regard to the thermal conductivity of gases in the Knudsen regime and effective properties of packed-beds modeled as a pseudo-homogeneous medium. A mathematical model of the freeze-drying of single microparticles and its outcomes are first presented. Data outcomes from the mathematical model at the macroscale concerning the drying behavior of microparticles in a tray and in a vial are then presented and can be used for process design. Some further data, with detailed interpretation and discussion of the presented data, can be found in the related research article, “A multi-scale computational framework for modelling the freeze-drying of microparticles in packed-beds”.

Supporting data and methods for the multi-scale modelling of freeze-drying of microparticles in packed beds / Capozzi, L. C.; Barresi, A. A.; Pisano, R.. - In: DATA IN BRIEF. - ISSN 2352-3409. - STAMPA. - 22:(2019), pp. 722-755. [10.1016/j.dib.2018.12.061]

Supporting data and methods for the multi-scale modelling of freeze-drying of microparticles in packed beds

Capozzi L. C.;Barresi A. A.;Pisano R.
2019

Abstract

A multi-scale approach can be used to simulate the drying behavior of microparticles in packed-bed. Data outcomes from discrete element method (DEM) and computational fluid dynamics (CFD) simulations can be used to estimate some relevant product characteristics, such as the porosity, tortuosity, voids in the bed and permeability which are required by the multi scale model. Data from DEM simulations are presented, with a particular focus on the influence of the model parameters, packing characteristics and inhomogeneities (wall effect and particles segregation); computational costs and scalability are also considered. Data on the properties of packings as modeled at the macroscale are presented with regard to the thermal conductivity of gases in the Knudsen regime and effective properties of packed-beds modeled as a pseudo-homogeneous medium. A mathematical model of the freeze-drying of single microparticles and its outcomes are first presented. Data outcomes from the mathematical model at the macroscale concerning the drying behavior of microparticles in a tray and in a vial are then presented and can be used for process design. Some further data, with detailed interpretation and discussion of the presented data, can be found in the related research article, “A multi-scale computational framework for modelling the freeze-drying of microparticles in packed-beds”.
File in questo prodotto:
File Dimensione Formato  
a-2019_DB_22(1)_722-755.pdf

accesso aperto

Descrizione: a-2019_DB_22(1)_722-755
Tipologia: 2a Post-print versione editoriale / Version of Record
Licenza: Creative commons
Dimensione 5.02 MB
Formato Adobe PDF
5.02 MB Adobe PDF Visualizza/Apri
Pubblicazioni consigliate

Caricamento pubblicazioni consigliate

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11583/2728276
 Attenzione

Attenzione! I dati visualizzati non sono stati sottoposti a validazione da parte dell'ateneo