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EnglishNowadays it is well known that alpha-cyclodextrins (αCDs-host) can form supramolecular structures, called poly pseudorotaxanes (PPRs), by threading along polymer chains of poly(ethyleneoxide) (PEO-guest)1. In this work, novel supramolecular systems have been developed using properly synthetized PEO-based polyurethanes (PU) and CDs. The self-assembling ability of these host-guest sytems was studied by dynamic light scattering (DLS), infrared (IR) and proton nuclear magnetic resonance (1H-NMR) spectroscopy. Then, bioartificial hydrogels from these materials with tunable mechanical and self-healing properties were characterizied through rheological tests. Cytocompatibility tests were performed on different hydrogels, to test their potential use in drug/gene delivery and cell encapsulation.
Supramolecular hydrogels based on host-guest complexes between custom-made polyurethanes and cyclodextrins / Torchio, Alessandro; Boffito, Monica; Cassino, Claudio; Ciardelli, Gianluca. - STAMPA. - (2018), pp. 79-79. ((Intervento presentato al convegno 9th BSRT symposium - The art of failure: Regenerative therapies from experimental sketches to clinical masterpieces tenutosi a Berlino nel 28-30 Novembre 2018.
| Titolo: | Supramolecular hydrogels based on host-guest complexes between custom-made polyurethanes and cyclodextrins |
| Autori: | |
| Data di pubblicazione: | 2018 |
| Abstract: | Nowadays it is well known that alpha-cyclodextrins (αCDs-host) can form supramolecular structures, called poly pseudorotaxanes (PPRs), by threading along polymer chains of poly(ethyleneoxide) (PEO-guest)1. In this work, novel supramolecular systems have been developed using properly synthetized PEO-based polyurethanes (PU) and CDs. The self-assembling ability of these host-guest sytems was studied by dynamic light scattering (DLS), infrared (IR) and proton nuclear magnetic resonance (1H-NMR) spectroscopy. Then, bioartificial hydrogels from these materials with tunable mechanical and self-healing properties were characterizied through rheological tests. Cytocompatibility tests were performed on different hydrogels, to test their potential use in drug/gene delivery and cell encapsulation. |
| Appare nelle tipologie: | 4.2 Abstract in Atti di convegno |
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