Supramolecular hydrogels based on host-guest complexes between custom-made polyurethanes and cyclodextrins

Torchio, Alessandro; Boffito, Monica; Claudio, Cassino; Ciardelli, Gianluca

PORTO @ Archivio Istituzionale della Ricerca

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Nowadays it is well known that alpha-cyclodextrins (αCDs-host) can form supramolecular structures, called poly pseudorotaxanes (PPRs), by threading along polymer chains of poly(ethyleneoxide) (PEO-guest)1. In this work, novel supramolecular systems have been developed using properly synthetized PEO-based polyurethanes (PU) and CDs. The self-assembling ability of these host-guest sytems was studied by dynamic light scattering (DLS), infrared (IR) and proton nuclear magnetic resonance (1H-NMR) spectroscopy. Then, bioartificial hydrogels from these materials with tunable mechanical and self-healing properties were characterizied through rheological tests. Cytocompatibility tests were performed on different hydrogels, to test their potential use in drug/gene delivery and cell encapsulation.

Titolo:	Supramolecular hydrogels based on host-guest complexes between custom-made polyurethanes and cyclodextrins
Autori:	TORCHIO, ALESSANDRO BOFFITO, MONICA Claudio Cassino CIARDELLI, GIANLUCA mostra contributor esterni nascondi contributor esterni
Data di pubblicazione:	2018
Abstract:	Nowadays it is well known that alpha-cyclodextrins (αCDs-host) can form supramolecular structures, called poly pseudorotaxanes (PPRs), by threading along polymer chains of poly(ethyleneoxide) (PEO-guest)1. In this work, novel supramolecular systems have been developed using properly synthetized PEO-based polyurethanes (PU) and CDs. The self-assembling ability of these host-guest sytems was studied by dynamic light scattering (DLS), infrared (IR) and proton nuclear magnetic resonance (1H-NMR) spectroscopy. Then, bioartificial hydrogels from these materials with tunable mechanical and self-healing properties were characterizied through rheological tests. Cytocompatibility tests were performed on different hydrogels, to test their potential use in drug/gene delivery and cell encapsulation.
Appare nelle tipologie:	4.2 Abstract in Atti di convegno

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http://hdl.handle.net/11583/2724860

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