An emulsification/internal setting technique for the preparation of coated and uncoated hybrid silica/alginate aerogel beads for controlled drug delivery

Bugnone, Cristiano Agostino; Ronchetti, Silvia; Manna, Luigi; Banchero, Mauro

doi:10.1016/j.supflu.2018.07.007

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Coated and uncoated hybrid silica/alginate aerogel beads have been prepared with a new emulsification/intemal setting technique. Hybrid aerogels combine high specific surface area and good mechanical strength of the inorganic component with biodegradability and bioadhesivity of the organic fraction so resulting in promising materials for drug-delivery. The hybrid beads were characterized through laser diffraction, BET and SAXS. Small particles (average diameter = 282 mu m) with high specific surface area (more. than 900 m(2)/g) and quite stable structural properties were obtained. Preliminary tests were performed to investigate how different kinds of coatings (alginate/hydroxypropyl methylcellulose, silica/hydroxypropyl methylcellulose or hydrophobic silica coating) affected the loading and release rate of model-drug ketoprofen. Among all results, uncoated hybrid aerogel beads resulted in burst release with 90% of the initial loaded drug delivered after 3 min while release was prolonged up to 60 min when a hydrophobic silica coating was used.

Titolo:	An emulsification/internal setting technique for the preparation of coated and uncoated hybrid silica/alginate aerogel beads for controlled drug delivery
Autori:	BUGNONE, CRISTIANO AGOSTINO RONCHETTI, SILVIA MARIA MANNA, LUIGI BANCHERO, MAURO
Data di pubblicazione:	2018
Rivista:	THE JOURNAL OF SUPERCRITICAL FLUIDS
Digital Object Identifier (DOI):	10.1016/j.supflu.2018.07.007
Appare nelle tipologie:	1.1 Articolo in rivista

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http://hdl.handle.net/11583/2719130

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