Anesthesia inducted with propofol is a nowadays largely adopted technique in hospital environments. The correct balancing of this compound is essential to avoid under- or over-dosages that may result in serious side-effects. Therefore, we are here presenting the design and the validation of a custom-made, low-cost and portable Point-of-Care (PoC) system based on electrochemical detection for propofol monitoring. Fouling phenomenon due to phenolic oxidation of propofol has been overcome by adopting a Pencil Graphite Electrode (PGE) 3H as sensor. The validation of the system focused on testing the measurement speed through scan-rate analysis, which is important due to the fast clearance of propofol metabolism; and on interference study with Paracetamol (APAP), since it is an analgesic compound frequently administered with propofol in medical practices.

Raspberry-Pi Based System for Propofol Monitoring / Stradolini, Francesca; Tuoheti, Abuduwaili; Kilic, Tugba; Demarchi, Danilo; Carrara, Sandro. - In: INTEGRATION. - ISSN 0167-9260. - 63:(2018), pp. 213-219. [10.1016/j.vlsi.2018.04.004]

Raspberry-Pi Based System for Propofol Monitoring

Abuduwaili Tuoheti;Danilo Demarchi;Sandro Carrara
2018

Abstract

Anesthesia inducted with propofol is a nowadays largely adopted technique in hospital environments. The correct balancing of this compound is essential to avoid under- or over-dosages that may result in serious side-effects. Therefore, we are here presenting the design and the validation of a custom-made, low-cost and portable Point-of-Care (PoC) system based on electrochemical detection for propofol monitoring. Fouling phenomenon due to phenolic oxidation of propofol has been overcome by adopting a Pencil Graphite Electrode (PGE) 3H as sensor. The validation of the system focused on testing the measurement speed through scan-rate analysis, which is important due to the fast clearance of propofol metabolism; and on interference study with Paracetamol (APAP), since it is an analgesic compound frequently administered with propofol in medical practices.
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Descrizione: Tuoheti Integration 2018
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11583/2705528
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