Following a thermodynamic approach, we develop a new theoretical analysis of ion transfer across cell membranes. Supported also by experimental data from the literature, we highlight that ion channels de- termine the typical features of cancer cells, i.e. independence from growth-regulatory signals, avoidance of apoptosis, indefinite proliferative potential, and the capability of inducing angiogenesis. Specifically, we analyse how ion transport, with particular regards to Ca 2 + fluxes, modulates cancer cell proliferation, and regulates cell cycle checkpoints. Finally, our analysis also suggests that in malignant tumours aerobic glycolysis is the more efficient metabolic process when taking the required solvent capacity into account.
The importance of ion fluxes for cancer proliferation and metastasis: A thermodynamic analysis / Lucia, Umberto; Deisboeck Thomas, S.. - In: JOURNAL OF THEORETICAL BIOLOGY. - ISSN 0022-5193. - STAMPA. - 445(2018), pp. 1-8. [10.1016/j.jtbi.2018.02.019]
Titolo: | The importance of ion fluxes for cancer proliferation and metastasis: A thermodynamic analysis | |
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Data di pubblicazione: | 2018 | |
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Digital Object Identifier (DOI): | http://dx.doi.org/10.1016/j.jtbi.2018.02.019 | |
Appare nelle tipologie: | 1.1 Articolo in rivista |
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http://hdl.handle.net/11583/2703070